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20. How Chemo Works

Chemo is like "carpet-bombing" whereas the new cell-targeted drugs are like "smart-bombs."


The Target...
chemo drugs are attracted to fast-growing cells, a chief characteristic of many cancer cells.
The Target
Ready...
Unless a cell can divide and replicate itself, the cell will die. Stopping cell division can stop cancer.
Aim
Aim...
All chemo drugs impair or disrupt cell division -- but they do so at different stages in the cell cycle.

 

 

 



Chemo drugs work at different cycles in the cells replication. For example, the chemo agent 5FU works at the "S Phase." A chemo "cocktail" could have three different agents each working at different phases of the cell cycle. There are about 60 approved chemo agents that can be effective in different combinations.
Collateral Damage... chemo also kills other fast growing cells in the body -- like those found in hair and intestines; that explains side effects like hair loss and nausea.
Fire

 

 

 

Fire... "cell kill" happens when chemo thwarts cell division; unable to replicate itself the cancer cells die off.